醫(yī)學(xué)論文范文:轉(zhuǎn)錄調(diào)節(jié)因子E26轉(zhuǎn)錄因子��1蛋白在胎膜早破中的表達(dá)和意義

醫(yī)學(xué)論文范文:轉(zhuǎn)錄調(diào)節(jié)因子E26轉(zhuǎn)錄因子��1蛋白在胎膜早破中的表達(dá)和意義

【摘要】 目的 探討E26轉(zhuǎn)錄因子��1(E26 transformation specific��1, Ets��1)蛋白在胎膜早破中的表達(dá)和意義。方法 采用免疫組織化學(xué)S�睵法在蛋白水平檢測(cè)75例胎膜早破者(病例組)及70例無(wú)其他產(chǎn)科并發(fā)癥及內(nèi)外科合并癥的足月?lián)衿谄蕦m產(chǎn)者(對(duì)照組)胎膜中Ets��1蛋白的表達(dá)。結(jié)果 ①Ets��1蛋白在胎膜滋養(yǎng)層細(xì)胞核及胞漿中均有表達(dá)，以胞核表達(dá)為主;②Ets��1蛋白在胎膜早破組滋養(yǎng)層中高表達(dá)，與對(duì)照組比較，有顯著性差異(P<0.05);③Ets��1蛋白在未足月胎膜早破組滋養(yǎng)層中高表達(dá)，但與足月胎膜早破組比較，無(wú)顯著性差異(P>0.05)。結(jié)論 轉(zhuǎn)錄調(diào)節(jié)因子Ets��1在人類胎膜上有表達(dá)，且在胎膜早破中高表達(dá)，表明Ets��1蛋白可能使胎膜細(xì)胞外基質(zhì)重塑從而引發(fā)胎膜早破。本研究可作為預(yù)測(cè)胎膜早破發(fā)生的依據(jù)。

【關(guān)鍵詞】 E26轉(zhuǎn)錄因子��1;細(xì)胞外基質(zhì);胎膜早破

Expression and clinical signficance of the transcription factorE26 transformation specific��1 in premature

rupture of fetal membranes

GUO Jing, GOU Wen�瞝i, SONG Qing

1. Department of Gynecology and Obstetrics, the First Affiliated Hospital, Medical School ofXi�餫n Jiaotong University, Xi�餫n 710061; 2. Department of Gynecology and Obstetrics,Xi�餫n Red Cross Hospital, Xi�餫n 710054, China

ABSTRACT: Objective To examine the expression and clinical significance of E26 transformation specific��1 in premature rupture of fetal membranes. Methods Fetal membranes from 75 women in the following categories were analyzed for Ets��1 expression: preterm and term premature rupture of fetal membranes; 70 women (control group) with term cesarean sections and without complications. Ets��1 protein was localized with the use of immunohistochemical S�睵 method. Results Ets��1 protein was expressed in both the nucleus and cytoplasm of trophoblast of human fetal membranes, with more obvious expression in the nucleus. Ets��1 protein�餾 expression was up�瞨egulated in the trophoblast of fetal membranes with premature rupture, which differed significantly from the control group (P<0.05). Ets��1 protein's expression was up�瞨egulated in the trophoblast of fetal membranes with preterm premature rupture, which did not differ significantly from the control group (P>0.05). Conclusion Ets��1 is expressed in human fetal membranes and its expression is up�瞨egulated with premature rupture of fetal membranes, suggesting a role for Ets��1 in extracellular matrix remodeling of the membranes. This study provides an evidence to predict premature rupture of fetal membrances醫(yī).學(xué)全.在.線網(wǎng)站zxtf.net.cn.

KEY WORDS: E26 transformation specific��1; extra cellular matrix; premature rupture of fetal membrane

胎膜早破(premature rupture of fetal membranes, PROM)是臨產(chǎn)前胎膜發(fā)生破裂，分為未足月胎膜早破(preterm premature rupture of fetal membranes, PPROM)和足月胎膜早破(term premature rupture of membranes, TPROM)，其發(fā)生率國(guó)內(nèi)報(bào)道為2.7%～17%，國(guó)外報(bào)道為5%～15%[1]。且發(fā)病率正逐年升高，其中約30%～40%胎膜早破并發(fā)早產(chǎn)，為新生兒發(fā)病率和病死率上升的一個(gè)重要原因。

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