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體外實(shí)驗(yàn)表明，適度低氧下MSCs的生長(zhǎng)和存活能力更好，產(chǎn)生集落形成單位的能力顯著增高，且干細(xì)胞標(biāo)志性基因表達(dá)水平更高[7]。氧濃度可以影響MSCs向成骨、成軟骨、成脂的分化傾向，低氧能提高特異性受體和配體相結(jié)合所介導(dǎo)的遷移。低氧誘導(dǎo)因子1信號(hào)通路[8]在MSCs對(duì)缺氧反應(yīng)的分子機(jī)制中占重要地位。
對(duì)缺氧反應(yīng)的分子機(jī)制本實(shí)驗(yàn)主要研究了CMS患者骨髓MSC的形態(tài)、表型、傳代能力、生長(zhǎng)曲線及擴(kuò)增能力等特征，其結(jié)果為CMS的研究提供了重要信息。但研究報(bào)道例數(shù)尚較少，結(jié)論還需要深入的體內(nèi)實(shí)驗(yàn)及分子生物學(xué)研究支持。
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