學(xué)科專長(zhǎng)和研究方向：
主要研究領(lǐng)域?yàn)槊谀蛳的[瘤、泌尿微創(chuàng)外科及前列腺疾病。近年來(lái)，作為主要負(fù)責(zé)人參與基因工程制藥，腹腔鏡器械研發(fā)zxtf.net.cn，醫(yī)學(xué)可視化技術(shù)等工作。
在研的主要項(xiàng)目：
saRNA上調(diào)Par-4基因表達(dá)的若干機(jī)制及其治療前列腺癌的實(shí)驗(yàn)研究（國(guó)家自然科學(xué)基金，30973466)
saRNAs上調(diào)前列腺癌中若干腫瘤抑制基因表達(dá)的機(jī)制研究(浙江省自然科學(xué)基金重點(diǎn)項(xiàng)目，Z2090356)
RNAs基因激活技術(shù)篩選前列腺癌靶標(biāo)及其作用的研究 （國(guó)家自然科學(xué)基金，30772176)
熒光原位雜交技術(shù)檢測(cè)膀胱癌分子細(xì)胞遺傳學(xué)變異的臨床應(yīng)用研究（衛(wèi)生部)
TGF-β受體缺陷型基因轉(zhuǎn)染腫瘤特異性CD8+細(xì)胞治療膀胱癌的研究（省部共建)
前列腺增生癥及其合并癥合理化治療方案的研究(國(guó)家科技支撐計(jì)劃, 2006BAI02B00)
代表論文：
1. Li Y, Yang K, Mao Q, Zheng X, Kong D, Xie L*. Inhibition of TGF-beta receptor I by siRNA suppresses the motility and invasiveness of T24 bladder cancer cells via modulation of integrins and matrix metalloproteinase. Int Urol Nephrol. 2009 Aug 8. [Epub ahead of print]
2. Mao Q, Zheng X, Jia X, Wang Y, Qin J, Yang K, Bai Y, Xie L*. Relationships between total/free prostate-specific antigen and prostate volume in Chinese men with biopsy-proven benign prostatic hyperplasia. Int Urol Nephrol. 2009 Feb 18. [Epub ahead of print].
3. Yan TZ, Jin FS, Xie LP, Li LC. Relationship between Glucocorticoid Receptor Signal Pathway and Androgen-Independent Prostate Cancer. Urol Int. 2008; 81: 228-233.
4. Mao QQ, Li YB, Zheng XY, Yang K, Shen HF, Qin J, Bai Y, Kong DB, Jia XL, Xie LP*. Up-regulation of E-cadherin by small activating RNA inhibits cell invasion and migration in 5637 human bladder cancer cells. Biochem Biophys Res Commun. 2008, 375(4): 566-570.
5. Jiang J, Zheng X, Qin J, Zheng M, Mao Q, Zhang Z, Cai S, Xie L*. Health-related quality of life after hand-assisted laparoscopic and open radical nephrectomies of renal cell carcinoma. Int Urol Nephrol. 2009; 41(1):23-7.
6. Zheng XY, Xie LP*, Wang YY, Ding W, Yang K, Shen HF, Qin J, Bai Y, Chen ZD.The use of prostate specific antigen (PSA) density in detecting prostate cancer in Chinese men with PSA levels of 4-10 ng/mL.J Cancer Res Clin Oncol. 2008 Nov; 134(11): 1207-10.
7. Yang K, Zheng XY, Qin J, Wang YB, Bai Y, Mao QQ, Wan Q, Wu ZM, Xie LP*. Up-regulation of p21 (WAF1/Cip1) by saRNA induces G1-phase arrest and apoptosis in T24 human bladder cancer cells. Cancer Lett. 2008 Jul 8; 265(2): 206-214.
