姓 名：吳武田
性 別：男
職 稱(chēng)：教授
學(xué) 歷：博士研究生
何種導(dǎo)師: 博士生導(dǎo)師
學(xué)科專(zhuān)業(yè)：人體解剖與組織胚胎學(xué); 神經(jīng)生物學(xué)
研究方向：神經(jīng)損傷和再生機(jī)制的基礎(chǔ)研究
行政職務(wù)：
學(xué)術(shù)兼職:
聯(lián)系方式: E-mail: wtwu@hkucc.hku.hk
電話(huà)：(852)28199187(O)
一般簡(jiǎn)介:
吳武田, 神經(jīng)科學(xué)博士,博士生導(dǎo)師。1988-1991年，美國(guó)Graduate School of Old Domonion University and Eastern Virginia Medical School的神經(jīng)科學(xué)博士；1992-1996年，美國(guó)Eastern Virginia Medical School神經(jīng)科學(xué)系，助理教授，1996-1997年香港大學(xué)解剖系，助理教授。1997年至今，香港大學(xué)醫(yī)學(xué)院解剖學(xué)系，副教授。中山大學(xué)客座教授。Journal of Histochem Cyrochem、Brain research、Experimental Neurology和Journal of Comparative Neurology的審稿專(zhuān)家；美國(guó)PVA脊髓研究基金委員會(huì)、美國(guó)Paralysis研究基金會(huì)評(píng)審專(zhuān)家。第四軍醫(yī)大學(xué)客座教授，中山大學(xué)客座教授。近20年來(lái)，吳武田博士一直致力于“神經(jīng)損傷和再生機(jī)制的基礎(chǔ)研究”，先后承擔(dān)美國(guó)科研基金5項(xiàng)，其中有NIH基金，香港科研基金8項(xiàng)，發(fā)表論文80篇，被引頻次1000余次，直接指導(dǎo)博士生9名，博士后10名。吳武田博士是脊髓損傷研究領(lǐng)域的國(guó)際知名學(xué)者，曾四次應(yīng)邀在國(guó)際神經(jīng)科學(xué)會(huì)議上作：“神經(jīng)移植、NOS在神經(jīng)損傷和再生中的作用”的專(zhuān)題報(bào)告。并應(yīng)邀參編著名神經(jīng)科學(xué)叢書(shū)：“Handbook of Chemical Neuroanatomy”。還作為分課題負(fù)責(zé)人承擔(dān)2003-2008年 國(guó)家科技部重大項(xiàng)目基金(973項(xiàng)目)---“神經(jīng)損傷的修復(fù)和重建的應(yīng)用研究”。
主要科研論文如下:
1.Yaun, Q, Wu, W., So, K-F: Inflammatory response of spinal motoneurons to axonal injury in newborn rats. Developmental Neuroscience, 25:65-71, 2003. (Wu, W: corresponding author).
2.Xie, Y.Y., Yao, Z.B., Chai, H., Wong, W.M. and Wu, W.: Re-expression and regulation of low-ffinity nerve growth factor receptor (p75) in spinal motor neurons of aged rats following axonal injury. Developmental Neuroscience, 25:71-78, 2003. (Wu, W: corresponding author).
3.Xie, Y.Y., Yao, Z.B., Chai, H., Wong, W.M. and Wu, W.: Potential roles of Alzheimer precursor protein A4 and b-Amyloid in the survival and function of aged spinal motor neurons following axonal injuries. J. Neuroscience Research, 73:557-564, 2003. (Wu, W: corresponding author).
4.Gu, H.Y., Chai, H., Zhang, J.Y., Yao, Z.B., Zhou, L.H., Bruce, I. and Wu, W.*: Survival, regeneration and functional recovery of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion. Europ. J. Neurosci. 19:2123-2131, 2004. (Wu W., corresponding author).
5.Yick,L-W., So, K-F, Cheung, P.T. and Wu, W.*: Lithium chloride reinforces the regeneration-promoting effect of chondroitinase ABC on rubrospinal neurons after spinal cord injury. J. of Neirotrauma, 21(7):932-943, 2004. (Impact:2.866; Citation:2). 50%
6.Wu, W.*, Chai, H., Zhang J.Y., Gu, H.Y., Xie, Y.Y. and Zhou, L.H.: Delayed implantation of a peripheral nerve graft reduces motoneuron survival but does not affect regeneration following spinal root avulsion in adult rats. J. of Neurotrauma, 21(8): 1050-1058, 2004. (Wu W., corresponding author).
7.Gu, H.Y., Chai, H., Zhang, J.Y., Yao, Z.B., Zhou, L.H., Wong, W.M., Bruce, I. and Wu, W.*: Survival, regeneration and functional recovery of motoneurons after delayed reimplantation of ventral root in adult rat. Exp. Neurol. 192:89-99, 2005. (Wu W., corresponding author).
8.Zeng Y.S., Ding, Y., Wu, L.Z., Guo, J.S., Li, H.B. and Wu, W.*: Co-transplantation of Schwann cells promotes the survival and differentiation of neural stem cells transplanted into the injured spinal cord. Dev. Neurosci. 27:20-26, 2005. (Wu W., corresponding author).
9.Zhou, LH and Wu, W.*: Antisense oligos to neuronal nitric oxide synthase aggravate motoneuron death induced by spinal root avulsion in adult rat. Exp. Neurol.197:84-92. 2006. (Wu W., corresponding author).
10.Yuan, QJ, Scott, DE, So,KF, Wu, W.*: Developmental changes of nitric oxide synthase expression in the rat hypothalamo-neurohypophyseal system. Anat. Record. 288A:36-45, 2006. (Wu W., corresponding author).
11.Yang, Y., Xie, Y.Y., Chai, H., Fan, F., Liu, S.H., Liu, H., Bruce, I., and Wu, W.*: Microarray Analysis of Gene Expression Patterns in Adult Spinal Motoneurons after Different types of Axonal Injuries. Brain Res. 1075:1-12, 2006. (Wu W., corresponding author). 醫(yī)學(xué).全.在線(xiàn).網(wǎng).站.提供
12.Yuan, QJ; Hu, B; So, KF; Wu, W.*: Age-related reexpression of p75 in axotomized motoneurons. NeuroReport, 17:711-715, 2006. (Wu W., corresponding author).
13.張偉,曾園山,吳武田,陳雅云,陳穗君.體外誘導(dǎo)的皮膚源性神經(jīng)干細(xì)胞在大鼠受損傷脊髓內(nèi)的存活、分化和遷移。解剖學(xué)報(bào), 2006,37(3):360-363
14.劉佛林，王琳琳，周麗華，吳國(guó)珍，吳武田.銀杏葉提取物減輕臂叢根性撕脫傷脊髓運(yùn)動(dòng)神經(jīng)元超微結(jié)構(gòu)的損傷。解剖學(xué)雜志，2006，29（1)：68-71.
15.李芳瀾, 周麗華,袁群芳, 姚志彬，吳武田. EGb761增強(qiáng)c-jun表達(dá)減少軸突撕脫后運(yùn)動(dòng)神經(jīng)元的死亡. 中國(guó)病理生理雜志, 2004, 10, 20(10)：1783~1785.
