浙江大學(xué)醫(yī)學(xué)院生物化學(xué)與分子生物學(xué)教授項(xiàng)春生個(gè)人信息

的研究中，采用DNA芯片技術(shù)篩選出新的轉(zhuǎn)錄調(diào)控因子Dec2，并揭示了Th2細(xì)胞分化的調(diào)控網(wǎng)絡(luò)，有助于了解Th2細(xì)胞介導(dǎo)的過敏性疾病的發(fā)病機(jī)制，還為過敏性疾病的治療提供了一個(gè)新的藥物靶點(diǎn)。曾獲美國NRC科學(xué)研究獎(jiǎng)和多項(xiàng)NIH特殊貢獻(xiàn)獎(jiǎng)。近幾年來在國際SCI雜志發(fā)表多篇學(xué)術(shù)論文，其中包括Nature Biotechnology, Nature Immunology, Nature Methods, Journal of Immunology, Nucleic Acids Research, Diabetologia，Endocrinology等權(quán)威學(xué)術(shù)期刊zxtf.net.cn，獲得過多項(xiàng)科學(xué)研究基金，包括NIH生物防御重大專項(xiàng)經(jīng)費(fèi)、美國國防部基金和國家973項(xiàng)目支持（項(xiàng)目首席科學(xué)家)等。所發(fā)表的論文影響因子累計(jì)100多點(diǎn)，他引次數(shù)200以上。獲科研經(jīng)費(fèi)總額超過600萬美元和1500萬人民幣。

主要論文：(* corresponding author)
Leu, S-W., L. Shi, C. Xu, Y. Zhao, B. Liu, Y. Li, A. Shiedlin, C. Xiang, D.A. Quinn, C.A. Hales and H. Zhao. 2010. TLR4 through IFN-gamma Promotes Low-Molecular-Weight Hyaluronan-Induced Neutrophil Apoptosis. Journal of Immunology. Acceptecd.

Ling, Z. and C. Xiang*. 2010. Infectofenomics: aspect of host responses to microbes in digestive tract. In Metagenomics of the Human Body. Edited by Karen E Nelson, Springer.

Ling Z, J. Kong, F. Liu, H. Zhu, X. Chen, Y. Wang, L. Li, K.E. Nelson, Y. Xia and C. Xiang*. 2010. Molecular analysis of the diversity of vaginal microbiota associated with bacterial vaginosis. BMC Genomics, 11: 488-503.

Ling, Z., J. Kong, P. Jia, C. Wei, Y. Wang, Z. Pan, W. Huang, L. Li, H. Chen and C. Xiang*. 2010. Analysis of oral microbiota in children with dental caries by PCR-DGGE and barcoded pyrosequencing. Microbial Ecology. 60(3): 677-690.

Liu, F., X. Mou, N. Zhao, J. Lin, L. Teng and C. Xiang*. 2010. Prevalence of Human Papillomavirus (HPV) in Chinese patients with colorectal cancer. Colorectal Disease. 2010 May 28. [Epub ahead of print] PMID: 20528894.

Liu, Z., Z. Li, K. Mao, J. Zou, Y. Wang, Z. Tao, G. Lin, L. Tian, Y. Ji, X. Wu, X. Zhu, S. Sun, W. Chen, C. Xiang* and B. Sun. 2009. Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling. Journal of Immunology. 183(10): 6320-6329.zxtf.net.cn

Shi, M., W. Deng, E. Bi, K. Mao, Y. Ji, G. Lin, X. Wu, Z. Tao, Z. Li, X. Cai, S. Sun, C. Xiang* and B. Sun. 2008. TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation. Nature Immunology. 9(4): 369-377.

Xiang, C., Y.J. Wu, L. Ma, I. Lisinski, M.J. Brownstein, S.W. Cushman and X. Chen. 2007. Dynamic Changes in Adipocyte Metabolism, Gene Expression and Adipokine Dysregulation in Insulin Resistance. Diabetologia. 50(5): 1070-1079.

Hansen, A., Y. Chen, J.M. Inman, Q. N. Phan, Z.Q. Qi, C.C. Xiang, N. Cherman, S.A. Kuznetsov, P. G. Robey, E. Mezey, and M.J. Brownstein. 2007. A sensitive and specific method for detecting G-protein coupled receptor mRNAs reveals the receptor repertoire of human bone marrow stromal cells. Nature Methods. 4(1): 35-37.

Chen, Y., B. Samal, C.R. Hamelink, C. Xiang, Y. Chen, M. Chen, D. Vaudry, M.J. Brownstein, J.M. Hallenbeck and L.E. Eiden. 2006. Neuroprotection by endogenous and exogenous PACAP following stroke. Regulatory Peptides. 137(1-2):4-19.

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